For patients of kidney disease, check the blood creatinine increased renal function will mean his kidney function beginning occurrence damage, the damage on your kidneys with medical statement that serum creatinine increased for kidney function on behalf of renal units have been more serious damage. Therefore, the vast majority of kidney disease patients in treatment, staring at blood creatinine is down, creatinine drop is pleased, creatinine high or the same is sorrow, especially renal failure, uremia patients. Should say, kidney disease patients mood is understandable, also is normal. But, healing the law of healing, is your may. To completely eliminate and lasting serum creatinine high phenomenon, from high blood creatinine trouble: renal fibrosis to start.
According to shijiazhuang kidney hospital of expert of study that found the renal fibrosis is lead to a variety of causes of renal injury, is a cause of chronic kidney disease progression end-stage renal failure into the pathological damage process, it is all sorts of chronic kidney disease clinical symptoms such as protein, hematuria, high blood pressure, anemia, creatinine high, urea nitrogen high and so on of the trouble.
The source of the kidney disease is caused by the various causes kidney local microcirculation, prompting kidney ischemia of oxygen. Because blood anoxic, the kidney damage the blood vessels of the endothelial cells. Kidney blood capillary endothelial cells once damaged, it will attract circulating inflammatory cells infiltration, and release the pathogenic inflammatory medium (IL-1, TNF-α, etc), which started the process of renal fibrosis.
Renal fibrosis once was launched, will continue to produce and release a series of renal toxicity of cell factors and growth factor (PDGF, TGF-beta). This causes kidney toxicity factor can cause kidney function cells (department membrane cells, epithelial cells, fibroblasts) phenotypes transformation. One especially in kidney function of interstitial into fiber cell phenotype converted, can secrete, synthetic not easily by a series of collagen protein degradation (the extracellular matrix-ECM). Formation continue to increase due to the ECM, undermining the kidney to maintain ECM synthesis and degradation of dynamic balance mechanism, cause kidney inside the extracellular matrix (ECM) synthetic increase and degradation function is reduced, eventually leading to a large number of extracellular matrix deposition and gathered themselves together. As a result of the many deposits and gathered, the gathered ECM replaced the function of health kidney unit, lead to glomerular sclerosis, continue to renal tubular--fibrosis, kidney vessels fibrosis.
The progress of the renal fibrosis, the function gradually reduce renal units, renal persistent decline, when the remaining to take the body's metabolic produce kidney function of creatinine eduction body outside, on patients' blood creatinine increased gradually, and finally fibrosis process development into the scar tissue, and the functions of the kidney unit almost all be destroyed, the function is lost, at this time will develop kidney in clinical into end-stage kidney failure-uremia.
So, the serum creatinine increased renal fibrosis is an apple of discord. Treatment of serum creatinine increased problem, we must start from the trouble of the renal fibrosis block, so that we can get the exact and lasting curative effect!
