High Creatinine and Renal Failure of the Relationship

In healthy adults do renal procuratorial, creatinine project for 40-umol normal/L. Blood creatinine available as the test kidney damage degree of powerful one of the index, if blood creatinine beyond normal reference value range, is that the patient kidney happened fibrosis lesions, kidney began to drop off.
At present, the blood creatinine for 200, belongs to the renal insufficiency of decompensated stage. This period of kidney disease patients because of glomerular filtration function decline is not serious and renal damage only accounts for a small part of the overall kidney function, so patients with renal function of the human body still can maintain internal environment balance, so, no matter the blood creatinine beyond the normal range, but rarely in patients with typical clinical symptoms of kidney disease.
Because of this stage, and no obvious discomfort with feeling, often easily ignored the diagnosis and treatment of disease, cause kidney disease exacerbated progress. For damage kidneys do not try to standardized treatment, kidney ongoing fibrosis of the lesion was expanded, kidney will be progressive decline, the ultimate result in patients of glomerular filtration function continuously decline, serum creatinine levels rising. With the course of the delay, patients will gradually entered the chronic renal insufficiency decompensated period, chronic renal failure period, even progress to kidney failure.
As for you say high serum creatinine is kidney failure, it is not so, the blood creatinine reach 707 umol/L above is kidney failure, but as long as higher than normal blood creatinine will pay attention, deal with treatment in time, can make an illness not progress become kidney failure. If is the application of some drop creatinine drugs can only on the surface of reduced blood creatinine, and not to repair the basement membrane, repair damaged kidneys organization, this is not the high serum creatinine drop, even if the decline, it is temporary, run into the inducing factors, soon rises again.
Comprehensive treatment, the cause of glomerular basement membrane injury immune complex and pathological tissues, and repair the glomerular basement membrane. As long as the damaged basement membrane after repair, change the kidney structure, expanded the glomerular filtration area, creatinine will natural decline, but this need a process, this time must prevent a cold, control diet and emotional, don't tired, handling blood pressure, blood sugar and other factors, take good care of renal function. As long as pay attention to it, the blood creatinine will drop to normal.

Reduce creatinine can eat meat

Reduce creatinine can eat meat? Creatinine high patients besides the choice good treatment for the diet to do scientific planning, diet and treatment is not divided, creatinine high patients can not eat meat?
In the lower creatinine also need to add enough energy, but these are limited, not blind blind fill, want to have the science diet, so, creatinine high patients should how to diet?
1, creatinine high demand for high-quality diet high protein:
Because the patient appears nitrogen qualitative hematic disease, renal insufficiency, in order to control the kidney continue to deteriorate, should control protein intake, choose rich in high quality high grade protein diet. Such as fish, lean lean, etc.
2, creatinine high patients requirements limit salt diet:
Renal insufficiency compensatory period, nitrogen quality of disease patients began to appear all sorts of slight clinical symptoms, because pathological damage not heavy, renal insufficiency only kidney failure high serum creatinine, but no less urine, no swelling patients can't help salt and water, maintain a low salt diet. If there is a severe swelling, and high blood pressure or even the heart failure should be strictly restricted the salt. Principle is to eat less.

Why we have Anemia of Renal Failure

Why Anemia of Renal Failure? There is inhibition of erythropoiesis in chronic renal failure or uremia plasma substances, inhibit in vitro cell culture in erythroid progenitorcells to mature, later proved to inhibit erythroid colony-forming units (CFU-E) proliferationand the synthesis of hemoglobin, spermine, spermidine and guanidine PTH in the bodythrough the destruction of the hematopoietic microenvironment to suppress bone marrow function.
Bleeding tendency caused by platelet dysfunction in patients with chronic renal failureand bleeding, especially bleeding from the digestive tract and skin, although not the direct cause of renal anemia, but can aggravate and promote the occurrence of anemia.
Renal damage, involving to generate EPO cells, the EPO produced gradually decreasedwith the progression of the disease, so that the bone marrow erythroid cells generateslow down. But it was found that the blood of patients with renal failure, EPO levels were normal or above normal, speculated that there may be EPO relative lack of. . In recent years, recombinant human erythropoietin erythropoietin (rhEPO) treatment of renal anemia to obtain satisfactory results.
Why Anemia of Renal Failure? A survey shows that renal failure patients with red blood cells shorten the life span of extracellular factors, red blood cells in patients withnormal recipients entered into the body, normal red blood cell life, the contrary, the normal donor red blood cells enter the uremia by the body, and its red blood cellsshortened life expectancy after dialysis back to normal, red blood cell life also proves thispoint.
This phenomenon with the plasma of patients with renal failure, however there are certain substances interfere with red blood cell membrane Na pump function, increasederythrocyte fragility. In addition, the metabolic disorder of red blood cells the pentose phosphate bypass NADPH to generate reduced glutathione to reduce, not eliminate theperoxide in the body, so that the increase in oxygen free radicals, resulting in the red cell membrane lipid peroxidation. Visible:
1. platelet dysfunction result in gastric mucosa of chronic bleeding, caused by iron loss;
2. hemodialysis plasma residue in the dialysis membrane and dialyzer Louxue;
3. frequent blood tests. Folate deficiency is more common in hemodialysis patients. Iron and folic acid deficiency affect hemoglobin synthesis.
Renal failure patients with anemia how to treat it?

Patients with kidney failure, why is there anemia

Normal kidney has the secretion of erythropoietin (hereinafter referred to as promote red element or EPO) function, because of various factors result in kidney dirty promote red element to produce inadequacy or uremia plasma interference of red blood cells are toxic to some generation and metabolism and cause anemia called renal anemia. Chronic renal failure, the kidney and red element relative shortage or cannot secrete promote red element is the main cause of anemia
For renal anemia what are the treatment measures
Promote red element with treatment blood transfusion treatment kidney transplant
A, blood transfusion treatment and promote red element with what are the different treatment
Promote red element treatment blood transfusion treatment is safe, effective, suitable for long time treatment to avoid the nervous advantages can source blood faster correction of anemia suitable for patients with severe anemia require treatment two weeks later they effect is not suitable for rescue and correct severe anemia faults increase infection (hepatitis, AIDS) transfusion reactions: fever, allergies, such as promoting the red element suppress hemolysis secretion, and bone marrow hematopoietic function of blood transfusion immune response and reduce renal transplantation, and to increase the success rate blood volume too much heart burden
In short, for a blood transfusion bring many adverse effects, in addition to the emergency rescue the illness must be a blood transfusion, chronic renal failure cause anemia, should choose to promote red element treatment
Second, red element of usage, the dose, the treatment for staging and treatment
Usage promote red element generally USES the subcutaneous or intravenous, subcutaneous injection amount smaller, more long curative effect
Staging period and correct treatment is divided into two stages maintenance phase
Treatment usually a treatment period for 8-12 weeks, fastest 3 weeks
Doses correct) : because the early treatment more serious anemia, promote red meat consumption to big, general is 2000-3000 IU, three times a week, make HB achieve 10-12 grams, HCT 30%-35%, and then to maintain period. Maintenance phase: dose in half or reduced to a third, which USES 2000 IU or 3000 IU, once a week to maintain long-term

Kidney failure causes anemia reason what?

Anemia is not really a disease, but many of the symptoms of the disease, and renal failure of anemia is also in their everyday life in one of the most common. The expert points out, the kidney failure can lead to anemia appear, mostly because blood is enough, perfusion defect so, cause kidney failure anemia the specific reason for the what?
The cause of the kidney failure anemia, kidney failure affect 1 hematopoietic: chronic kidney failure, besides kidneys produced erythropoietin parts of the damaged outside, hemoglobin to oxygen affinity reduce, the unit hemoglobin to oxygen increase the utilization rate of, kidney ischemia relative not serious, produce erythropoietin the main stimulus to reduce, leading to the generation of erythropoietin significantly less. And toxins inhibit bone marrow, chronic renal failure in some of the accumulation of the blood of the marrow is toxic to direct inhibition and lead to hematopoiesis function obstacle.
Renal failure reason 2, renal failure of anemia in red blood cell damage: some of chronic renal failure of red blood cell in patients with anaemia caused by increased damage is also one of the reasons why, this is because the uremia disease was high when the red blood cells to shorten life, can happen, uremia red blood cells and red blood cell metabolic barrier when brittle increase, the resulting red blood cells, capillary pathological changes made by mechanical damage and destruction red blood cells, spleen function hyperthyroidism.
Therefore, if the body without symptoms of anemia appear, to promptly to the hospital for examination, to prevent illness further intensifies, the happening of the result in kidney failure.