Why we have Anemia of Renal Failure

Why Anemia of Renal Failure? There is inhibition of erythropoiesis in chronic renal failure or uremia plasma substances, inhibit in vitro cell culture in erythroid progenitorcells to mature, later proved to inhibit erythroid colony-forming units (CFU-E) proliferationand the synthesis of hemoglobin, spermine, spermidine and guanidine PTH in the bodythrough the destruction of the hematopoietic microenvironment to suppress bone marrow function.
Bleeding tendency caused by platelet dysfunction in patients with chronic renal failureand bleeding, especially bleeding from the digestive tract and skin, although not the direct cause of renal anemia, but can aggravate and promote the occurrence of anemia.
Renal damage, involving to generate EPO cells, the EPO produced gradually decreasedwith the progression of the disease, so that the bone marrow erythroid cells generateslow down. But it was found that the blood of patients with renal failure, EPO levels were normal or above normal, speculated that there may be EPO relative lack of. . In recent years, recombinant human erythropoietin erythropoietin (rhEPO) treatment of renal anemia to obtain satisfactory results.
Why Anemia of Renal Failure? A survey shows that renal failure patients with red blood cells shorten the life span of extracellular factors, red blood cells in patients withnormal recipients entered into the body, normal red blood cell life, the contrary, the normal donor red blood cells enter the uremia by the body, and its red blood cellsshortened life expectancy after dialysis back to normal, red blood cell life also proves thispoint.
This phenomenon with the plasma of patients with renal failure, however there are certain substances interfere with red blood cell membrane Na pump function, increasederythrocyte fragility. In addition, the metabolic disorder of red blood cells the pentose phosphate bypass NADPH to generate reduced glutathione to reduce, not eliminate theperoxide in the body, so that the increase in oxygen free radicals, resulting in the red cell membrane lipid peroxidation. Visible:
1. platelet dysfunction result in gastric mucosa of chronic bleeding, caused by iron loss;
2. hemodialysis plasma residue in the dialysis membrane and dialyzer Louxue;
3. frequent blood tests. Folate deficiency is more common in hemodialysis patients. Iron and folic acid deficiency affect hemoglobin synthesis.
Renal failure patients with anemia how to treat it?