Creatinine 400 means the patient to renal insufficiency of kidney failure, according to different creatinine, people will be divided into four kidney damage) :
(1) of compensatory serum creatinine 141.4 ~ 177. O micrograms of molecular/L
(1.6 ~ 2.0 mg/dl), kidney unit by 20% ~ 25%, through the compensatory renal
excretion and adjusting function is good, if have albuminuria, patients with
mild since morning eyelid edema can be, but generally have no obvious
(2) decompensated period (i.e. quality of nitrogen disease) blood creatinine
185.9 ~ 442.6 mmol/L (2.1 ~ 5.0 mg/dl), kidney unit by 50% ~ 70%, renal
excretion and adjusting function decline, appear nocturia more, lack of power,
edema, anorexia, nausea and mild anemia, occasionally acidosis.
(3) decompensation of advanced (namely the uremia) blood creatinine >
442.6 ~ 708.2 micrograms of molecular/L (5.0 ~ 8.0 mg/dl), kidney unit by 70% ~
90%, patients often severe anemia, oedema, can have nausea, vomiting, metabolic
acidosis, hypocalcemia and hyperphosphatemia.
(4) uremic stage blood creatinine > 708.2 micrograms of molecular/liter
(8.0 mg/dl), the whole body poisoning symptoms serious, have a lot more water in
the body for storage.
Creatinine for patients to have reached 400 in the later stage of the kidney
damage, the patient has the kidney damage to 70% above, early kidney damage
treatment is not seasonable, with inflammatory lesions caused further
intensifies, make the function of the kidneys healthy cell had the phenotype
transformation, released a series of causes kidney toxicity cells and growth
chemotactic agent, and synthesis, secretion lots of not easily by the
degradation of the extracellular matrix. Because of synthesis and degradation of
dynamic balance mechanism of disorders, and a lot of extracellular matrix
deposits and gathered, replacing the health function units, appeared glomerular
sclerosis; Renal tubular degeneration and atrophy; Interstitial organization,
blood vessels and fibrosis. So a lot of creatinine row do not go out, happened
high creatinine and renal failure.