High Creatinine and Renal Failure 400?

Creatinine 400 means the patient to renal insufficiency of kidney failure, according to different creatinine, people will be divided into four kidney damage) :
(1) of compensatory serum creatinine 141.4 ~ 177. O micrograms of molecular/L (1.6 ~ 2.0 mg/dl), kidney unit by 20% ~ 25%, through the compensatory renal excretion and adjusting function is good, if have albuminuria, patients with mild since morning eyelid edema can be, but generally have no obvious self-conscious symptom.
(2) decompensated period (i.e. quality of nitrogen disease) blood creatinine 185.9 ~ 442.6 mmol/L (2.1 ~ 5.0 mg/dl), kidney unit by 50% ~ 70%, renal excretion and adjusting function decline, appear nocturia more, lack of power, edema, anorexia, nausea and mild anemia, occasionally acidosis.
(3) decompensation of advanced (namely the uremia) blood creatinine > 442.6 ~ 708.2 micrograms of molecular/L (5.0 ~ 8.0 mg/dl), kidney unit by 70% ~ 90%, patients often severe anemia, oedema, can have nausea, vomiting, metabolic acidosis, hypocalcemia and hyperphosphatemia.
(4) uremic stage blood creatinine > 708.2 micrograms of molecular/liter (8.0 mg/dl), the whole body poisoning symptoms serious, have a lot more water in the body for storage.
Creatinine for patients to have reached 400 in the later stage of the kidney damage, the patient has the kidney damage to 70% above, early kidney damage treatment is not seasonable, with inflammatory lesions caused further intensifies, make the function of the kidneys healthy cell had the phenotype transformation, released a series of causes kidney toxicity cells and growth chemotactic agent, and synthesis, secretion lots of not easily by the degradation of the extracellular matrix. Because of synthesis and degradation of dynamic balance mechanism of disorders, and a lot of extracellular matrix deposits and gathered, replacing the health function units, appeared glomerular sclerosis; Renal tubular degeneration and atrophy; Interstitial organization, blood vessels and fibrosis. So a lot of creatinine row do not go out, happened high creatinine and renal failure.