Why would have increased serum creatinine with kidney failure?

Why would have High Creatinine and Renal Failure? Blood creatinine increases, is most patients with kidney failure will appear symptoms, renal hospital in the kidney disease experts said, creatinine is a human body of a normal metabolism product, usually his normal is 40-120 umol/L, when the value is more than creatinine may explain your kidney function appear damage, leading to row poison function drops, body endotoxin row out, so creatinine increases.
Why would have High Creatinine and Renal Failure? Authoritative experts say high serum creatinine, explain nephrosis patient's kidney function has been badly damaged, should have the function that discharge poison kidney unit by fibrous tissue replaced, lead to row poison function drops, body endotoxin row a, creatinine will heighten. At the same time also will be accompanied by a series of poisoning the clinical symptoms and multiple organ damage symptoms, such as anemia, high blood pressure, serious electrolyte metabolic disorder and acidosis, etc. The key lies in the treatment of renal fibrosis blocking progress continuously, repair pathological damage early fibrosis, restore the structure of normal kidney tissue of the functional status, creatinine natural decrease. If not treated, creatinine continuously, serious will progress to kidney failure, and even late renal failure, uremia, threatening the life safety of patients with severe.