Why creatinine increases nephrotic syndrome?

Serum creatinine surface high reason of kidney damage kidneys cannot micturition, essence and serum creatinine high is caused by kidney in the various causes of infringement by kidney cells after inherent damaged, happen fibrosis. First the damaged kidney cell had phenotype inherent transformation, form the pathological changes, stimulate in kidney fibroblasts into muscle fibroblasts, and at the same time and inspired the infringement inherent normal kidney tissues, the same lesions occur, thus creating the kidney transference, from part to the overall, and expand the spread of JiFaShi process, thus into the quality of the damage (namely renal damage period), at this time due to damage to the kidney continuously, the discharge waste function decrease, created the toxin in the body, creatinine gathered themselves together, and thus appear in blood serum creatinine, urea nitrogen increases, urine creatinine drop, double kidney filtration rate, etc. At the same time patients will have high blood pressure, high swelling and other body other symptoms.
Why creatinine increases nephrotic syndrome? Is due to kidney in the various causes of infringement by, first the damaged kidney cell had phenotype inherent transformation, form the pathological changes, stimulate in kidney fibroblasts into muscle fibroblasts, and at the same time and inspired the infringement inherent normal kidney tissues, the same lesions occur, thus creating the kidney transference, from part to the overall, and expand the spread of JiFaShi process, thus into the quality of the damage (namely renal damage period), at this time due to damage to the kidney continuously, the discharge waste function decrease, created the toxin in the body, creatinine gathered themselves together, and thus appear in blood serum creatinine, urea nitrogen increases, urine creatinine drop, double kidney filtration rate, etc. At the same time patients will have high blood pressure, high swelling and other body other symptoms.