Kidney failure and creatinine will high

One,the reason of high creatinine
Creatinine muscle in the body is the product of metabolism, each 20 g muscle metabolism can produce 1 mg creatinine. Creatinine mainly by the glomerular (kidney is an important part of) filtration eliminated from the body. Blood creatinine from exogenous and endogenous two kinds, exogenous creatinine is meat food in the metabolism of the products; Endogenous creatinine muscle tissue metabolism is the body of the product. At the meat food intake are stable. The body's muscles metabolism and no big changes, the generation of creatinine is constant.
High creatinine was due to various causes of kidney is infringed, first the damaged kidney cell had phenotype inherent transformation, form the pathological changes, stimulate in kidney fibroblasts into muscle fibroblasts, and at the same time and inspired the infringement inherent normal kidney tissues, the same lesions occur, thus creating the kidney transference, from part to the overall, and expand the spread of JiFaShi process, thus into the quality of the damage (namely renal damage period), at this time due to damage to the kidney continuously, the discharge waste function decrease, created the toxin in the body, creatinine gathered themselves together, and thus appear in blood serum creatinine, urea nitrogen rising, urine creatinine drop, double kidney filtration rate drop, etc. At the same time patients will have high blood pressure, high swelling and other body other symptoms.

Second, the cause of the kidney failure
When patients of kidney function normal, such material from glomerular filtration urine from the bodies. Renal damage, such material from kidney row not to go out, but after intestinal waste eliminated from the body.
Half of the cases of the material in the body produces speed for 1 mg/minutes, glomerular also at the same speed put it cleared away. When kidney function decline to certain degree, and the material can rise, but when its normal renal function mechanism, the material also can appear higher. When left normal renal function of the three points at that time, the kidney compensatory, this material to apparently rise, so the material is not the sensitivity of the index of function of glomerular filtration. This kind of material is normal 40-120 umol/L, muscle atrophy, thin body, factors such as pregnancy can make such substances slightly low level of kidney failure. This could explain the material indicators and was not accurate in reflecting the stand or fall of renal function.