Saturday 2 June 2012

Children with nephrotic syndrome, the etiology and classification

Children of nephrotic syndrome is proteinuria (24-hour urinary protein more than 3.5 g) tall lipemia and different level of clinical syndrome features. Common causes of glomerular disease by (such as primary glomerular inflammation, glomerular focal sclerosis, etc), secondary glomerulonephritis (such as diabetic nephropathy with lupus kidney disease, etc) and secondary infection (such as bacteria, viruses, etc), the circulation system disease, drug poisoning cause. Children early basement membrane lesions nephrotic syndrome is lighter, along with lesions gradually progress, a lot of protein urine from the bodies, which was reduced plasma protein important reasons. The fall in the levels of plasma protein, especially the albumin significantly, cause plasma colloid osmotic pressure drop, prompted the blood vessels in the blood vessels to the liquid, cause tissue edema and effective capacity drops of blood. The children produced nephrotic syndrome hyperlipidemia mechanism is not very clear.
Before the onset of the children often upper respiratory tract infection history, mild edema only performance in the morning, eyelid edema, the person that weigh the whole body, pitting oedema scrotal edema performance light, severe swelling have ascites and chest water, the children often tired, anorexia, WeiMi spirit, pale face wait for a symptom, the children immune function is low, so often have infection, if not timely treatment can be combined with hypovolemic shock, electrolyte imbalance vascular blockage and acute renal failure, etc. Available adrenal cortical hormone and combining traditional treatment.
The upper respiratory tract infection is inducement
Children's respiratory infections, such as colds, tonsillitis, acute pharyngitis, if not to the timely and effective control of infection, in 1 ~ 4 weeks after may induce nephrotic syndrome. In general, children nephrotic syndrome have early signs of infection, its outstanding characteristic is 3 tall one low, namely high dropsy, high protein, high cholesterol and hypoalbuminemia. Tiny disease degeneration nephrotic syndrome in age of onset two to six years old children, and boy more than girls, extremely easy recurrence and delay, the course of a long.
Little children because physique weaker, than normal immune cells less people, the immune function is not strong, so the immune cells not only sometimes devour the bacteria, but leave the bacteria inclusive up, the body of germs and bacteria itself with antibody into a kind of immune complex, with blood circulation, the kidney, the sedimentary glomerular basement membrane to, so as to have a kidney damage, make a loss of protein, eventually leading to the nephrotic syndrome.

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