What can lead to nephrotic syndrome proteinuria form

The emergence of the urinary protein, there may be a means of human kidney problems, so usually, a lot of people through the normal amount of urinary protein to determine whether the body health. Normally, for albuminuria, it may be possible to human kidney problems.
The kidney pathological changes of the renal fibrosis is called, is the latest theory with the current kidney disease. At present the renal fibrosis medical process is divided into three periods, namely the inflammatory lesions stage (induced phase), inflammation matrix formation, fibrosis scar formation. A lot of proteinuria happen throughout the kidney process fibrosis, is mainly because kidney was destroyed, filtration barrier basement membrane aperture expanding or fracture, and lead to protein leaks out. In the start stage renal fibrosis, i.e., inflammatory lesions stage, because all kinds of infections in the body self adjusting mechanism function disorder, generate different immune complex, and then these immune complex deposition in the different natural cell zone. These immune complex deposition, they will attract within the body of different types of inflammatory mediators, inflammatory mediators and immune complex a union, will lead to a variety of types of inflammation, these inflammatory response will stimulate the kidney cells, the inherent cells in sedimentary destruction damage.
When kidney function cells are damaged, can cause kidney local microcirculation, organization will cause a series of oxygen for ischemia and inflammation, and then further damage the kidneys inherent cells. Kidney cells damaged produce inflammation response once, glomerular local will appear "high filtration, high perfusion, high pressure inside the" three tenors symptoms, glomerular local will have pathological changes, such as the mesangium cell hyperplasia, membrane matrix is increasing, the basement membrane filtration aperture increase or closure, or the basement membrane rupture, charge barrier damage, these changes, glomerular filtration function is reduced, permeability increase.