Saturday 9 June 2012

How should we treat kidney failure and anemia

Patients with kidney failure are different levels of anemia, more severe anemia,. Anemia is kidney failure patients see more symptoms, but different anemia in patients with different level, the cause of the anemia in patients with renal failure of red blood cell is to generate important increase, the destruction of the red blood cells to increase and incur the emergence of anemia. If accompanied by bleeding, more easily cause or mitigate anemia.
1, red blood cell production increase:
2, red blood cell production interfere with:
3, red blood cell be destroyed:
4, bleeding indirect cause:
Patients with kidney failure of all kinds of reason often accompanied by bleeding tendency, such as nasal bleeding, subcutaneous bleeding, such as gastrointestinal bleeding, these symptoms of anemia in patients with indirect incurred.
So how can we treat anemia and renal failure?
1, red blood cell transfusion can be correction of anemia, but temporary repeated blood transfusions can cause iron accumulation (secondary blood disease), blood product of infectious disease caused such as viral hepatitis, malaria, AIDS, etc.
2, promote cells use genetic restructuring erythropoietin (EPO), the dosage is 50 ~ 75 IU/kg, subcutaneous injection, every week 3, until the red blood cells deposited 30%, hemoglobin to 100 g/L for 25 to 50 when reducing IU/kg, 2 times per week to maintain drug use.
EPO treatment kidney failure anemia, definite effect, but the price is expensive. Common use EPO subcutaneous injection in its blood half life of 15 hours of, use a few days later nets woven reduce red blood cells, and then hemoglobin is reduced, drug use six weeks correction of anemia (hemoglobin weekly growth 1.0 g/L or so), drug use curative effect is bad in bone marrow fibrosis, hemolysis, nutrient bad (protein, iron or vitamin), bleeding. Correction should be paid attention to. Abundant dialysis and correction of anemia renal failure with EPO.

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